Three prisoners fled away from Hyderabad Civil Hospital, on Friday (today).
The three prisoners were shifted to the hospital from the central jail on the complaints of illness.
However, they managed to run away from the hospital.
The police have started search operation and have shut down nearby areas.
Earlier in 2017, two prisoners, Shaikh Muhammad Mumtaz alias Firoon and Muhammad Ahmed Khan alias Muna escaped from the judicial complex of Central Prison Karachi.
Acording to the details, both the prisoners fled away through breaking the grill of the jail.
jail staff came to know about their escape when they were supposed to be presented before the court inside the jail.
In a similar incident, hundreds of prisoners fled during an exchange of fire between security forces and militants after a mass jailbreak in Jalalabad city of Afghanistan.
Spokesman for the governor of Nangarhar province, Attaullah Khugyani said that more than 300 prisoners were still at large.